Anticonvulsant « Go Back
  • FEB – CZR
  • Qualitative & Quantitative Composition.

    Each suppository contains Diazepam I.P. 2.5mg / 5mg
    In Suppository base
  • Dosage Form

    Suppositories
  • Therapeutic indications

    Anticonvulsant
  • Directions

    Suppository should be moistened with water before inserting.
    Not to be taken by mouth.
    For rectal administration only.
  • Dosage and administration

    For treatment of febrile seizures: 0.2 - 0.5 mg/kg, repeated after 15 minutes if necessary.
    Treatment of recurrences of febrile seizures: Given only when child is sick with fever 0.2 - 0.5 mg/kg 8th hrly whenever temperature is >38.5oC can be used.
    As directed by physician
  • Contra-indications

    Hypersensitivity, myasthenia gravis, preexisting CNS depression or coma, respiratory depression, acute pulmonary insufficiency or sleep apnoea syndrome, severe hepatic impairment, acute narrow angle glaucoma, pregnancy and lactation.
  • Warnings and Precautions

    Impaired renal and hepatic function, respiratory disease, organic cerebral changes, elderly, psychotic patients, epileptics, history of alcohol or drug addiction, impaired gag reflux, obese patients. May cause CNS depression. Discontinue treatment if patient develops psychiatric and paradoxical reactions. Caution when used in patients with depression or anxiety associated with depression, especially if patient has suicidal risk. May increase risk of falls. Safety and efficacy of the inj have not been established in children < 1 mth of age. Safety and efficacy of oral use have not been established in children <6 mth of age. Safety and efficacy of rectal gel have not been established in children < 2 yr of age. Abrupt withdrawal or large dose reduction may cause rebound or withdrawal symptoms.
  • Drug interactions

    Increased clearance of diazepam when used with phenytoin, carbamazepine and phenobarbital. Reversible deterioration of parkinsonism may occur when given together with levodopa. Combination with lithium may produce hypothermia. May need to reduce dose of narcotics when used concurrently. Potentially Fatal: Increased clearance of diazepam when used with phenytoin, carbamazepine and phenobarbital. Reversible deterioration of parkinsonism may occur when given together with levodopa. Combination with lithium may produce hypothermia. May need to reduce dose of narcotics when used concurrently.
  • Pregnancy & lactation

    NA
  • Undesirable effects/side effects

    Drowsiness, sedation, muscle weakness, and atexia are the most frequent adverse effects of diazepam use. They generally decrease on continued dosage and are a consequence of CNS depression. Less frequent effects include vertigo, headache, confusion, depression, slurred speech or dysarthria, changes in libido, tremor, visual disturbances, changes in salivation, and amnesia.
  • Overdose

    Should not exceed the stated dose without any doctor's advice. Symptoms of overdose: Somnolence, confusion, coma, diminished reflexes.