Article published in The Bombay Hospital Journal (Vol.34, No. 4, 1992, PP. 35-40)
In a double blind placebo controlled trial, 205 patients suffering from pulmonary tuberculosis receiving isoniazid, rifampicin, ethambutol and streptomycin were studied for effect of simultaneous administration of Hepatogard 3 Tablets 3 times a day during 1st two months of intensive therapy on the incidence of hepatotoxicity and clinical morbidity. No patients in drug treated group developed jaundice whereas one patient from controls developed jaundice. Overall incidence of abnormalities in liver function tests was low, but more number of patients in controls tended to record abnormal values than the drug treated patients.
Rapid restoration of appetite and feeling of well being was observed in drug treated group. Significant differences in favor of drug treatment were observed in the pattern of weight gain at the end of 8 weeks of treatment. No serious adverse effects attributable to Hepatogard treatment were observed.
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