Effect of prophylactic HEPATOGARD treatment on the incidence of hepatotoxicity in patients receiving anti – tuberculosis drugs

Article published in The Bombay Hospital Journal (Vol.34, No. 4, 1992, PP. 35-40)

Summary

In a double blind placebo controlled trial, 205 patients suffering from pulmonary tuberculosis receiving isoniazid, rifampicin, ethambutol and streptomycin were studied for effect of simultaneous administration of Hepatogard 3 Tablets 3 times a day during 1st two months of intensive therapy on the incidence of hepatotoxicity and clinical morbidity. No patients in drug treated group developed jaundice whereas one patient from controls developed jaundice. Overall incidence of abnormalities in liver function tests was low, but more number of patients in controls tended to record abnormal values than the drug treated patients.

Rapid restoration of appetite and feeling of well being was observed in drug treated group. Significant differences in favor of drug treatment were observed in the pattern of weight gain at the end of 8 weeks of treatment. No serious adverse effects attributable to Hepatogard treatment were observed. 

Clinical trial of HEPATOGARD in acute viral hepatitis

Article published in The Indian Practitioner (Vol. XLVI, Feb 1993, No. 2, PP. 141-151)

Summary

In a double blind placebo controlled trial, Hepatogard, a herbal formulation was evaluated in 62 patients of acute viral hepatitis. The clinical parameters viz., anorexia, nausea-vomiting, malaise, icterus, liver tenderness and hepatomegaly decreased markedly on the drug as compared to the placebo. The total serum bilirubin was elevated in the placebo group at the end of four days while during the same period, total serum bilirubin values in Hepatogard group dropped.

The difference between the placebo and the drug was significant (P < 0.005). The decline continued to be significant for next three weeks. Similar significant decline in serum transaminase values was observed. No serious adverse effects were observed.

How Digital Transformation Is Affecting The Pharma And Healthcare Industry?

Digitalization is the new buzzword. It touches each and every aspect of our lives. How is it possible that the pharma and healthcare industry remains unaffected by it?

In fact, being a technology-driven industry, it gets the most benefits of digital transformation.

There are digital modes for better patient care. There are people willing to receive treatment and healthcare using the digital platform.

Every day, there are new modes of communication and apps available to users, and new technologies are being launched.

These advancements will start a new era that will lead to a new phase in the history of healthcare. Want to know about some points that underline the digital transformation? Read the blog further.

Changing the role of patients in the treatment

Digital transformation makes patients more active in the treatment process nowadays.  Earlier, the person had to fix an appointment with the doctor while seeking treatment for an ailment. He used to follow the instructions and administer the drugs prescribed.

With digitization, patients go prepared by doing online research. They match the symptoms and conditions. They talk to others who developed similar symptoms or problems.

Some try to device the cure as well.

Also, people are concerned about their fundamental rights. Also, people have much higher expectations from professionals than ever before.

Patients have better accessibility

The availability of the data is humongous, and it is increasing with every passing day. The days are gone when medical information was limited to journals, and it was restricted to limited forums.

Earlier, patients were disclosed information on a need basis only.

The digital revolution removes all the secrecy. Every bit of information is available to everyone at a click. People can find everything they wish by hitting a button. They can compare drugs and find a better alternative.

And it is all possible without spending a dime!

Personalized health tracking

People are health conscious today. The physicians also know it well. Hence, doctors suggest the patients these healthcare apps.

What is the aim of these apps? They make things simple for both doctors as well as patients. It is user-friendly, and convincing way of getting medical services and access to healthcare information.

It opens more communication channels

Digital presence opens various social media platforms, emailers, and hospital websites to connect to their healthcare specialists.

They can have online access to their medical records as well.

All these things revolutionize the pharma and healthcare industry.

6 Tips to Strengthen Immunity in Covid times

The recent COVID-19 pandemic has changed the world upside down.

Medical experts all over the world assert that building a strong immunity is one of the most important safety measures against the deadly virus. Strong immunity not only creates a barrier against foreign elements like germs and viruses but also helps the body in fighting against diseases by producing more white blood cells (WBC).

Let us now look at some healthy tips that can help in strengthening immunity:

Get proper sleep

Health experts assert that sleep and immunity are very closely related. They claim that while inadequate or improper sleep can make people susceptible to illnesses, getting adequate rest can help them in strengthening their immunity naturally. For instance, an adult body needs at least 7 to 8 hours of sleep every night.

Eat healthy

The gut contains a majority of the immune cells. This makes eating healthy and acknowledging good food behaviour pivotal for a strong immune system. Citrus fruits, garlic, ginger, leafy greens, almonds, etc. are some of the food items that can help boost immunity.

Add probiotics in daily diet

Probiotics are the healthy bacteria that are not only beneficial for a healthy digestive system but also for good immunity. Various studies assert that a flourishing network of gut bacteria helps the immune cells in differentiating between the healthy cells and harmful ones. People can consume fermented products like kefir, yoghurt, etc. as they are some of the best sources of probiotics.

Exercise

Regular exercising and working out is pivotal for boosting the body’s immune system. As per medical experts, it assists in rapid circulation of antibodies and white blood cells, eventually making the detection and removal of virus easy. Moreover, regular exercising also lowers down the level of stress hormones that can further minimize the risk of illnesses. Cardio exercises like running, cycling, swimming, etc. and yoga are some of the best exercises for strengthening immunity.

No smoking, No Drinking

Alcohol abuse and smoking are the two biggest enemies of the body’s immune system. Medical studies assert that cutting down on nicotine can improve the blood circulation, increase oxygen levels, and lower inflammation that can in turn boost immunity.

Consider Ayurveda

Ayurveda, also known as the “Science of Life”, is an ancient (Indian) system of natural and holistic medications. It propagates the gifts of nature for nourishing a healthy and happy life. For instance, the Ministry of Ayurveda, Yoga and Naturopathy (AYUSH) released a list of ayurvedic recommendations for boosting immunity amidst the COVID-19 outbreak. Some of the recommendations include:Consume warm water throughout the dayPractice Yogasana, Pranayam, or meditation for at least 30 minutes dailyUse jeera, haldi, dhaniya and garlic in cookingConsume 1tbs of chyavanprash in the morningDrink herbal tea or “Kadha” made from basil leaves, cinnamon, black pepper, dry ginger, and raisinDrink haldi milk daily

People should also ensure to maintain proper hydration levels throughout the day. For instance, adults should drink at least 3 to 4 litres of fluids each day. They can also take help of pharmaceutical products for immunity that are manufactured by the top pharma companies in India.

How to improve digestion naturally ?

Occasional digestive problems are a common complaint, and there are several possible causes, from diet to stress. Symptoms often go away on their own, but some simple home remedies can ease discomfort.

Common digestive problems include:

An unhealthful diet or lifestyle can cause more regular digestive problems, and lifestyle changes can often help resolve symptoms. A doctor can offer support and advice.

An underlying medical issue, a medication, or a food intolerance can also cause regular digestive discomfort.

Home remedies can help improve digestion in the short term. Lasting improvement may require more significant dietary or lifestyle changes.

1. Relax

Stress can affect the digestive system.

Many people experience an unsettled stomach before an exam or a big event, but sustained stress can affect the connection between the brain and the gut, causing ongoing problems.

There is a link between physical and mental health, and reducing stress can have a positive impact on both. The American Psychological Association recommend three key ways to manage stress:

  • having a good support network
  • getting regular exercise
  • getting enough sleep

During a busy day it can be tempting to rush meals, but this can cause indigestion and stomach discomfort. Take time to relax, particularly before and after eating.

Reducing stress by seeking support and making some lifestyle changes may improve problems with digestion.

2. Drink mint tea

Mint tea is a home remedy for nausea and indigestion. However, some people find that mint can contribute to heartburn or acid reflux.

To make a simple mint tea:

  1. Set aside 5–10 peppermint or spearmint leaves.
  2. Boil 1 cup of water and leave it to cool slightly.
  3. Pour the water over the leaves and steep for 3–5 minutes.
  4. Add a slice of lemon or a small amount of honey, if desired.

Researchers have found that peppermint oil may relieve symptoms of irritable bowel syndrome — including stomach pain — in the short term. However, there has been too little research to determine whether mint has lasting digestive

3. Take a walk

Doing gentle exercise can help with digestion. Being upright and active allows gravity to help move food through the digestive system.

A slow walk around the block, for example, may ease bloating and reduce feelings of fullness.

4. Reduce gas

Gas can come from swallowing air when eating or drinking. The body also produces gas when digesting food. Trapped gas in the gut can cause bloating and stomach discomfort.

Having a certain amount of gas is healthful, but some activities cause a person to swallow more air than usual, and this can increase the amount of gas in the body. Examples of these activities include:

  • chewing gum
  • drinking carbonated drinks
  • eating too quickly
  • wearing dentures that do not fit well

Certain foods create more gas when they go through the digestive system. These include:

  • broccoli
  • kidney beans
  • onions
  • apples
  • yogurt

Gently rubbing the belly can help gas move through the body, which can help reduce stomach discomfort and bloating.

5. Try fermented foods

Fermented foods have been partially or wholly broken down by microorganisms such as bacteria. These microorganisms work to preserve food, and they may also benefit gut health.

Bacteria occur naturally in the gut. Some help digest food, but others can cause problems with digestion if there are too many in the body. Fermented foods contain bacteria that may help support a healthy digestive system.

Some fermented foods include:

  • probiotic yogurt
  • sourdough bread
  • sauerkraut
  • kefir
  • miso

Incorporating these foods into the diet may help improve digestion. However, confirming the benefits will require more scientific research.

6. Eat more fiber

Fiber has a wide range of health benefits, from lowering cholestrol to reducing the risk of heart disease. It can also help improve digestion by regulating bowel movements.

According to national dietary guidelines, the average adult should include around 30 grams of fiber in their daily diet.

Good sources of fiber include:

  • whole grains
  • fruits and vegetables
  • beans

A person should also drink plenty of liquids to ensure that the fiber absorbs enough water to pass through the digestive system easily.

7. Keep a food diary

Some foods and drinks trigger problems with digestion. These triggers can vary from person to person, and keeping a food diary can help with identifying the culprits.

Make a note of meals, snacks, and drinks, as well as any digestive problems that follow. Then, try cutting out potentially problematic foods and drinks from the diet to see whether symptoms improve.

A nutritionist can provide guidance before a person makes any significant changes to their diet. A food diary will also help a medical professional gain a better understanding of the situation so that they can offer more specific advice.

8. Avoid these foods

While people react differently to different foods, some foods and drinks commonly cause problems with digestion.

Examples include:

  • processed foods
  • spices
  • fried foods
  • acidic foods, such as vinegar and citrus fruits
  • sweeteners, such as fructose
  • alcohol
  • caffeine

Limiting the intake of these can help improve digestion.

Also, fast foods and ready-made meals are high in sugar, salt, and saturated fats. They can be harder for the body to digest and cause problems such as constipation and gas.

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